Vascular calcification is a common and severe complication of diabetes mellitus which affects more than 9% of the American population. Together, our results suggest that GSK3β inhibition reduces vascular calcification in diabetic arteries through a similar mechanism to that in Mgp −/− mice. We also find that the alterations in β-catenin and SMAD1 by GSK3β inhibition in the aortic endothelium of diabetic Ins2 Akita/wt mice are similar to Mgp −/− mice. Cell lineage tracing reveals that GSK3β inhibition redirects endothelial cell (EC)-derived osteoblast-like cells back to endothelial lineage in the diabetic endothelium of Ins2 Akita/wt mice. Here, we report that GSK3β inhibition reduces vascular calcification in diabetic Ins2 Akita/wt mice. In our previous study, we showed that glycogen synthase kinase-3β (GSK3β) inhibition induces β-catenin and reduces mothers against DPP homolog 1 (SMAD1) to direct osteoblast-like cells toward endothelial lineage, thereby reducing vascular calcification in Matrix Gla Protein (Mgp) deficiency. Academic Software for Emory Students (Personal Purchase)Įmory students can purchase academic software for personal use from Kivuto Solutions, an Emory reseller partner.Endothelial–mesenchymal transition (EndMT) drives the endothelium to contribute to vascular calcification in diabetes mellitus. Work at Home Software for Emory EmployeesĮmory employees can purchase discounted academic software to use for Emory business on personal computers from Kivuto Solutions, an Emory reseller partner. Tech ToolsĪ website for campus IT professionals for enterprise software applications and other tools to support their clients. If you need technical assistance after completing your software download, please contact your local support department. A valid Emory University Net ID is required for access. Many of the University’s software titles are available by download at this website, where employees and students have access to products that they’re eligible to use. Software Distribution, a service of OIT Applications Support, administers academic software licensed by the University and also consults with faculty, staff and students about products they need.
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